Endocrine Abstracts

Introduction: Factitious hypoglycemia results from surreptitious administration of insulin or insulin secretagogues. It can involve non-diabetic individuals with knowledge of hypoglycemiant drugs, or diabetics manipulating the doses.Clinical case: A 42-year-old women, type 1 diabetic since the age of 14, on intensive insulin therapy (A1C: 8.5%), was hospitalized for study of recurrent severe hypoglycemia in the last 2 months, despite successive insulin d...

Thyrotropin-secreting pituitary tumors are <1% of pituitary adenomas. Clinical manifestations are similar to other forms of hyperthyroidism. Most of them are diagnosed as macroadenoma (microadenomas <10%).Case 1: A 48 years old woman with menopause presented 6 years ago, consulting in 2009 for weight loss and palpitations. She had elastic goiter and distal tremor. Blood test: TSH 8.66 μUI/ml (0.2–4.2), FT4 4.7 ng/dl (0.7&#150...

Introduction: Radioiodine (RAI) therapy is an inexpensive and reliable therapeutic option for Graves’ disease (GD). However, individual characteristics of the disease can influence therapeutic success. The identification of these factors may help to predict outcome and select optimal pre-treatment conditions.Aim: To assess clinical, laboratory and radioactive parameters that may lead to RAI treatment failure in patients with GD....

Introduction: Methimazole is the thionamide compound most used in the treatment of hyperthyroidism due to its efficacy, commodity and security. Severe side effects are rare, although potentially fatal: agranulocytosis in 0.1–0.5% and toxic hepatitis in 0.1%Aims: To characterize the patients admitted in the endocrinology ward for the last 10 years for severe complications of methimazole therapy.Material and Methods: Retrospecti...

Introduction: Data on body composition in patients with achondroplasia are scarce. The Phase Angle (PA) is a bioelectric measurement of our body cells. The PA is considered to be a global prognostic factor that gives information about cellular function in relation to body composition.Objectives: To describe body composition parameters PA, standardized PA (sPA), resistance (Rz), reactance (Xc), body cell mass (BCM), total body water (TBW), fat mass (FM), ...

Introduction: Non-classical congenital adrenal hyperplasia (NCCAH) due to 21-hydroxylase deficiency is one of the most frequent autosomal recessive diseases. Genetic analysis performed for genetic counselling revealed a miscorrelation with the clinical diagnosis in several patients at our centre.Aim: Confirm the genetic diagnosis of NCCAH in women attended for this condition.Materials and methods: Consecutive patients attended at o...

Introduction: Pituitary tumors can be classified according to their endocrine function, starting from the clinical phenotype to establish a diagnosis. The histological analysis can confirm the clinical suspicion. A thorough classification is essential in the therapeutic approach with an important influence in the disease-free survival.Case report: We report a case of a 16-year-old male, with loss of visual acuity and headache, attended by an Ophthalmolog...

Introduction: Cushing’s disease (CD) is a Grave disease that requires a multidisciplinary and individualized treatment approach.Case report: We describe the case of a 31-years old female patient with Cushing disease diagnosed in 2007. She initially complained of weight fluctuations, amenorrheia, rounded face with plethora and acne, for 1 year duration. Analytically: 0800 h plasma cortisol of 14 μg/dl (5–25) and 2300 h 15 μg/dl, ACTH 1...

Objective: Relationship between pre-pregnancy BMI (PPBMI) in gestational diabetic (GD) patients, and age, country of origin, family history of type 2 diabetes mellitus (T2DM), GD history, and BMI after pregnancy.Methods: Transversal, descriptive study of 259 consecutive pregnant with confirmed DG. Analysis were based on Fisher’s exact test and Student’s t-test. A P<0.05 was significant (SPSS 19.0).Re...

Introduction: Type one diabetes is estimated to account for 1% of the pregnancies complicated by diabetes, associated with an increased risk of maternal and perinatal morbidity. The multidisciplinary follow up of the diabetic women can contribute to an improvement of the glycemic control, minimizing the obstetric and perinatal complications.Aims: To characterize pregnant women with type one diabetes followed in our Department’s Endocrinology/Obstetr...